SCLERO-EZE a chang shan SUPPLEMENT
February 12, 2012 | Editor's Pick
By Cathryn Delude, Harvard Medical School Communications
For roughly 2,000 years, Chinese herbalists have treated malaria using a root extract, commonly known as chang shan, from a type of hydrangea that grows in Tibet and Nepal. More recent studies suggest that halofuginone, a compound derived from this extract’s bioactive ingredient, could be used to treat many autoimmune disorders as well. Now, researchers from the Harvard School of Dental Medicine have discovered the molecular secrets behind this herbal extract’s power. To view full article click here!
Amino Acid Proline
Havard Researchers were able to identify a single amino acid, called proline playing a dynamic role in the development of the inflammatory T-helper 17 cells. Halofuginone and Febrifugine Derivatives Inhibited the Synthesis of the Amino Acid Proline in the Development of These T-helper 17 Cells. Other researchers have discovered, a dietary reduction of proline will result in a measurable reduction in blood plasma levels; however, it is unknown if such reduction will enhance the therapeutic effects of the febrifugine derivatives.
Various nutritional health food stores sell the amino acid Proline as concentrated food supplement. However, autoimmune sufferers should avoid consuming the amino acid proline in any nutritional supplements without the explicit consent or advice of a physician. While proline may be very beneficial for an individual seeking to gain weight or muscle mass it may be detrimental for autoimmune sufferers. It is advisable to check the food supplement label and read exactly what is in it.
Consumers are becoming aware that Gluten Free is a good thing. WHY? The chemical composition of gluten contains approximately 40% of these two amino acids: proline and glutamic. Interestingly, if you ate a diet devoid of proline your body can convert glutamic acid into proline acid. So, a diet which reduces both proline and glutamic acid may be the best - Consider the Paleo Diet. Just as a side note, if you have ever been hospitalized even for a short duration you mostly likely were offered Jell-O..... Jell-O is one of the highest food sources for the amino acid proline!
Meanwhile, there is no singular pill (drug) or food source that can offer the Fountain Of Youth; rather, it is an orchestrated event of nutrients and micronutrients. Simplistically stated: there are foods that nourish the body and there are others that cause chaos. Just as the immune response may be divided into two components innate and adaptive ... the food you consume can be filled with nutrients and micronutrients supporting the good bacterial growth of the digestive tract or the foods you consume can be filled with lectins, GMO's, harmful proteins that trigger an ever cascading adaptive response. The Paleo Diet simplifies the science in nutrition and makes choices manageable.
The T-helper 17 cells in there normal role provide anti-microbial immunity at the epithelial and mucosal barriers (innate immunity). An additional important function; they recruit- signal the development of additional t-helper 17 cells. This is important for a strong immune response which is occasionally needed...... not so when self attacks self -autoimmune. In the autoimmune (adaptive immunity) they become overactive creating inflammation and tissue injury. Opinions in the medical community are changing as to what causes Autoimmune Illnesses. Previously, most assumed science did not know! Now it is becoming apparent dietary choices are influencing the scientific discussion.
As previously stated, medical researchers have identified the inflammatory Th17 cells as playing the prominent role in these autoimmune-related disorders. Subsequently, there may be a measureable correlation in the degree of improvement when using SED rate tests as indicators. In essence, you may see a reduction in your SED rate prior to feeling the improvement in the body! An SED test is a blood test that measures overall or nonspecific inflammation in the body.
Hydrangea Root , Chang Shan: Not the same thing
Some individuals are taking Hydrangea Root (Tu Chang Shan) thinking it is the same as Chang Shan. But only Chang Shan contains trace amounts of the organic matrix for halofuginone.
Tu Chang Shan (Hydrangea Root) and Chang Shan (Dichroa Root) are two different herbs!
According to Wikipedia there are over 75 different flowering species of hydrangea. The Hydrangea Root sold in the U.S. is actually Hydrangea Arborescens (Tu Chang Shan). Its common name is Seven Barks, Wild Hydrangea a plant native to America.
The hydrangea is a stately flower native to the southeastern United States and northeastern Asia. It grows near water, hence its name. The grayish roots used in herbal medicine have little odor but a sweet and pungent taste. In the U.S. the Cherokee Indians were the first known to have observed the usefulness of the herb (Tu Chang Shan) in treating kidney stones.
Whereas, Chang Shan is a Chinese herb that has been used for over 2,000 years in Chinese medicine. Chang Shan (Dichroa febrifuga Latin botanical name)
Chang Shan (Dichroa Febrifuga) is one of 12 species of Dichroa flower plants in the family of Hydrangeaceae. It is native to eastern and southeastern Asia.
Genus: Dichroa, Family: Hydrangeaceae, Subfamily: Hydrangeoideae, Tribe: Hydrangeae.
Taking one of these herbs and expecting it will have the benefit of the other is like ... eating carrots and expecting to receive the nutritional benefit of red beets.