CHANG SHAN ....... "IN THE NEWS"

BIOMIMICRY: EMULATING NATURE’S GENIUS

Posted on June 22, 2013 by Jamal Ross

Chang shan (常山) is a medicinal herb that has been used for well over 2000 years in traditional Chinese medicine for the treatment of malaria. Its popularity has dwindled as the popular Artemisinin herb (青蒿素) has replaced much of its use. However, it has recently been discovered that Chang shan has a selective suppressive effect on the immune system. This property has led to its use in a range of autoimmune conditions such as rheumatoid arthritis, psoriasis and thyroiditis. In the past week I visited five different traditional chinese clinics with a hope to find out more information about this herb and its clinical use. All of the doctors I spoke to were aware of its use in malaria but were not aware of its recent application to autoimmune diseases. It seems as though this information has not yet trickled back down into the  traditional Chinese medical community.  To view full article click here!

 

 

Chinese Medicinal Herb Yields

The Scrippts Research Insitute  Jan 21, 2013  Volume 13.   Issue 2.   

The mysterious inner workings of Chang Shan—a Chinese herbal medicine used for thousands of years to treat fevers associated with malaria—have been uncovered thanks to a high-resolution structure solved at The Scripps Research Institute (TSRI). 

 Described recently in the journal Nature, the structure shows in atomic detail how a two-headed compound derived from the active ingredient in Chang Shan works. Scientists have known that this compound, called halofuginone (a derivative of the febrifugine), can suppress parts of the immune system—but nobody knew exactly how. 

The new structure shows that, like a wrench in the works, halofuginone jams the gears of a molecular machine that carries out “aminoacylation,” a crucial biological process that allows organisms to synthesize the proteins they need to live. Chang Shan, also known as Dichroa febrifuga Lour, probably helps with malarial fevers because traces of a halofuginone-like chemical in the herb interfere with this same process in malaria parasites, killing them in an infected person’s bloodstream.  To view full article click here!  

 

 

WebMD Health News By Jennifer Warner   Feb. 12, 2012 

Chinese Herb Targets       Secret Behind Chang Shan May 

Feb. 12, 2012 -- A new discovery about a 2,000-year-old Chinese herbal remedy derived from the roots of the blue evergreen hydrangea may pave the way for a new generation of targeted treatments for autoimmune disorders.

A new study suggests the Chinese herb known as Chang Shan selectively weakens the runaway immune response implicated in many autoimmune disorders, such as rheumatoid arthritismultiple sclerosis, and psoriasis.

Researchers say the active ingredient in the Chinese herbal remedy, halofuginone (HF), blocks the development of a harmful type of immune cell called Th17 cells without disabling the immune system altogether.  To view full article click here!  

 

 

NATURE CHEMICAL BIOLOGY  8311–317 (2012)   DOI:10.1038/NCHEMBIO.790 

RECEIVED 27 MAY 2011 ACCEPTED  22 NOVEMBER 2011   PUBLISHED ONLINE  12 FEBRUARY 2012

Febrifugine, the bioactive constituent of one of the 50 fundamental herbs of traditional Chinese medicine, has been characterized for its therapeutic activity, though its molecular target has remained unknown. Febrifugine derivatives have been used to treat malaria, cancer, fibrosis and inflammatory disease. We recently demonstrated that halofuginone (HF), a widely studied derivative of febrifugine, inhibits the development of TH17-driven autoimmunity in a mouse model of multiple sclerosis by activating the amino acid response (AAR) pathway.  Here we show that HF binds glutamyl-prolyl-tRNA synthetase (EPRS), inhibiting prolyl-tRNA synthetase activity; this inhibition is reversed by the addition of exogenous proline or EPRS. We further show that inhibition of EPRS underlies the broad bioactivities of this family of natural product derivatives. This work both explains the molecular mechanism of a promising family of therapeutics and highlights the AAR pathway as an important drug target for promoting inflammatory resolution.  To view full article click here! 

 

 

 

FOCUS     News from Havard Medical, Dental and Public Health Schools   July 10, 2009  

A small molecule better known for its anti-malarial properties can block the birth of the immune cells involved in autoimmune diseases without blocking crucial infection-fighting cells, report Harvard Medical and Dental School researchers. The findings in the June 5 Science suggest a potentially new therapeutic approach for some autoimmune diseases.

The molecule, called halofuginone, is derived from roots of a plant in the hydrangea family,Dichroa febrifuga, or blue evergreen hydrangea, which grows in Asia and is used in Chinese herbal medicine.  To view full article click here!  

 

 

WebMD Health News By Daniel J Denoon   June 4, 2009 

Chinese Herb May 

Study Shows Herb From Hydrangea Root Targets 

A drug derived from an herb used in Chinese medicine for 2,000 years is the first to target specific cells that are overactive inrheumatoid arthritis, psoriasis, and other autoimmune diseases. 

The ancient herb is chang shan, from the root of the blue evergreen hydrangea. It's been used in Chinese medicine to reduce fever and fight malaria.The ancient herb is chang shan, from the root of the blue evergreen hydrangea. It's been used in Chinese medicine to reduce fever and fight malaria. To view full article click here! 

 

Development in Motion: Helper T Cells at Work

Steven L. Reiner1,* 1  Abramson Family Cancer Research Institute and Department of Medicine,

University of Pennsylvania, Philadelphia, PA 19104, USA

*Correspondence: sreiner@mail.med.upenn.edu

DOI 10.1016/j.cell.2007.03.019

In mammals, helper T cells orchestrate defense against diverse pathogens. However, these warriors of the immune system can also result in self-inflicted injury culminating in 

autoimmune and allergic diseases.   Recent findings—such as the discovery of the Th17 lineage—have revealed additional complexity in the fates chosen by helper T cells and have begun to reshape our view of how signaling and transcriptional networks generate appropriate and inappropriate immunity.  To view full article click here!   

 

 

CIRCUITRY OF CELLS INVOLVED IN IMMUNITY, AUTOIMMUNE DISEASES EXPOSED

Thu, 03/07/2013 - 10:09am   Haley Bridger, Broad Communications

New work from the Broad Institute’s Klarman Cell Observatory, Brigham and Women’s Hospital, Harvard University, MIT, and Yale University expands the understanding of how one type of immune cell—known as a T helper 17 or Th17 cell—develops, and how its growth influences the development of immune responses. By figuring out how these cells are “wired,” the researchers make a surprising connection between autoimmunity and salt consumption, highlighting the interplay of genetics and environmental factors in disease susceptibility. The results of their work appear in three companion papers in Nature this week.   To view full article click here! 

 

We welcome other articles on the Chinese herb Chang Shan

 

Pharmaceutical vs Nutraceuticals

Facts:   Feb 12, 2012  Approximately one-third of the top 20 drugs on the market today are derived from natural products, with the majority of these being derived from plants. Researchers from the Harvard School of Dental Medicine have discovered the molecular secrets behind The Chinese herb Chang Shan herbal extract’s power.  "This study is an exciting example of how solving the molecular mechanism of traditional herbal medicine can lead both to new insights into physiological regulation and to novel approaches to the treatment of disease," researcher Tracy Keller, an instructor in Whitman's lab, says in the release.

Facts:     Previously medical researchers had identified Halofuginone as a possible treatment for Rheumatoid Arthritis, Multiple Sclerosis and Scleroderma. Halofuginone is a drug derived from the ancient herb Chang Shan (Latin botanical name: dichroa root).

Facts:       Chang Shan is one of the 50 "fundamental herbs" of traditional Chinese medicine, according to the study. This herb has been used in Chinese medicine for more than 2,000 years as a treatment and has been used to reduce fever and fight malaria.

Facts:     Researchers have discovered that in the body, one common precursor T cell can give rise to both tissue-protective T regulatory, or Treg, cells and the inflammatory T cell type known as T helper 17.  These inflammatory Th17 cells play a prominent role in many autoimmune-related disorders, such as Rheumatoid Arthritis, Multiple Sclerosis, Inflammatory Bowel Disease and Psoriasis.

Facts:     Researchers have discovered Halofuginone and other febrifugine derivatives prevented inflammatory Th17 cells from emerging without interfering with tissue-protective Treg cells.  

Pharmaceutical companies have not shown an interest in developing Natural therapeutic treatments because these compounds are already available in the public domain.

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A message from the founder

In early 2003, the founder of SunCatcher Herbs, who is a Systemic Scleroderma sufferer  discovered the unique properties of the Chinese herb Chang Shan. Sclero-Eze, an advanced herbal supplement that uses Chang Shan as a base, was developed.

Historically, the Chinesed herb Chang Shan has been used as a natural treatment for fever and malaria dating back in Chinese lore at least two thousand years, to the Han dynasty (206 B.C.–A.D. 220).  During this era, information about the plant’s root (and about hundreds of other Chinese herbal remedies) first appeared as part of a written collection of oral traditions said to have originated with the mythological emperor-god Shen Nong in 2800 B.C.

Western medicine first noted the healing potential of the plant’s root extract, Chang Shan, in the late 1940s, when the active ingredient was identified in medical journals and put to use suppressing parasitic growth in animal feed.

The medical community has ignored the Chinese herb Chang Shan while focusing their efforts on a drug called halofuginone in the treatment numerous illnesses and diseases.

As a Community of Sufferers, we must demand information about all of the resources and treatment options available to us in the battle against these devastating diseases. There are many among us who will never consider an herbal supplement without the approval of the medical community.  However, it should be noted there is a great financial incentive to study a patentable drugs and very little motivation to investigate non patentable herbs.  We encourage you contact your political representatives and press upon them the need to study herbal supplements.

 

We at SunCatcher Herbs encourage you to consider this natural herbal supplement.

Discover for yourself the benefits of Sclero-Eze!

Ervin Gonzales

 

Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease. Dietary supplements are not intended to treat, cure, or prevent any disease.